Madan L. Nagpal

University of South Carolina

Research Associate Professor at the Department of Microbiology and Immunology, University of South Carolina, Columbia, SC, and Research Chemist at the Dorn Veterans Medical Center, Columbia, SC, USA for 10 plus years. He has published 40 research articles, 38 Abstracts and Presentations, a Book Chapter and edited a book. He was awarded Research & Productive Scholarship 1990 by the Univ. South Carolina. He was funded by the grants as Co-Investigator by National Institutes of Health (NIH) and the VA Merit Review grants. His contributions include gene regulation in steroid hormone biosynthesis and the characterization of Bacillus species. He is a member of American Society of Cell Biology, American Association of Advancement of Science, The Endocrine Society, Fellow Linnean Society of London, American Association for Laboratory Animal Science, International Who’s Who Professionals, and Marquis Who’s Who in America.

2books edited

2chapters authored

Latest work with IntechOpen by Madan L. Nagpal

Synthetic biology gives us a new hope because it combines various disciplines, such as genetics, chemistry, biology, molecular sciences, and other disciplines, and gives rise to a novel interdisciplinary science. We can foresee the creation of the new world of vegetation, animals, and humans with the interdisciplinary system of biological sciences. These articles are contributed by renowned experts in their fields. The field of synthetic biology is growing exponentially and opening up new avenues in multidisciplinary approaches by bringing together theoretical and applied aspects of science.

Go to the book

Synthetic Biology

Edited by Madan L. Nagpal

Books edited

Cholesterol

Edited by Madan L. Nagpal

Chapters authored

Disruption of Bradycardia During Vigilance: Autonomic Cardiac Dysregulation is Prelude to Disinhibition, Hyperarousal, and Attention Bias in Combat Veterans with PTSD

By Jay P. Ginsberg and Madan Nagpal

We propose a model to account for the post‐traumatic stress disorder (PTSD) symptoms of disinhibition, hyperarousal, and attention bias. We review the background literature which is the foundation on which our model rests, present key results of our ongoing research, and suggest testable hypotheses for further research. Our laboratory is in a Veterans Affairs (VA) Medical Center, where we began our work with a search for the significant causes and predictors of hyperarousal in combat veterans with PTSD using eyeblink and autonomic conditioning protocols. We believe our studies will lead to integration of a treatment intervention for war veterans (and equally as well for treatment of the traumatically stressed in the general population). Our research has begun to show strong associations between lowered heart rate variability (HRV) and PTSD. Loss of bradycardia during normal vigilance is the cause of lowered HRV, which impairs appraisal of threat value of environmental stimulation, thereby leading to disinhibition, hyperarousal, and attention bias toward and away from threat. The next steps of research we plan are outlined and designed to elucidate how HRV biofeedback is a promising intervention to increase HRV during vigilance of stimuli and restore cognitive appraisal and response selection, thereby reducing PTSD symptoms and normalizing behavior.

Part of the book: A Multidimensional Approach to Post-Traumatic Stress Disorder

Introductory Chapter: The Role of Genetic Engineering Technology in the Manipulation of Genetics of Organisms and Synthetic Biology

By Madan L. Nagpal

Part of the book: Synthetic Biology

Madan L. Nagpal

Latest work with IntechOpen by Madan L. Nagpal

Synthetic Biology

Books edited

Cholesterol

Chapters authored

Related collaborators

André Marchand

Heike Gerger

Ana Starcevic

Katia Levrier

Carolyn Leathead

Sophie Lacerte

Geneviève Belleville

Delphine-Emilie Bourdon

Melanie Vachon

Jens Gaab

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